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Grupa sanguină a unui individ rămâne neschimbată pe parcursul vieții, cu excepția cazurilor de transplant de măduvă sau prin adiția sau dispariția unor antigene în infecții, boli maligne sau boli autoimune, ce pot implica schimbarea grupei de sânge. După cum se observă, la un individ nu se pot găsi antigenul și aglutinina corespunzătoare. Serul fiecărui individ conține anticorpi împotriva antigenelor treatment nu există pe eritrocitele sale. Dacă antigenul eritrocitar intră în Make contact with cu anticorpul particular, se produce aglutinarea (agregare) și liza hematiilor.

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Genele ce controlează exprimarea acestor caractere antigenice eritrocitare se transmit ereditar, după legile mendeliene.

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Genotipul este dat de alelele situate pe cromozomii omologi, iar fenotipul este conturat prin prezența sau absența antigenelor pe suprafața eritrocitelor.Here